Understand, Design and Optimise Mixing in Stirred Tanks

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SSPC SFI Research Centre for Pharmaceuticals

University of Limerick



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Understand, Design and Optimise Mixing in Stirred Tanks. SSPC CFD Mixing Training for Industry - Modelling and Demonstrations

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DAY ONE: Thursday, March 19: Modelling

9:30am to 12:30 - SSPC members only Modelling Theme Meeting

13:00pm - 13:20pm - MixIT – Overview presentation using Finite Volume - Dr Gopal Rameshchandra Kasat

13:20pm - 13-40pm - M Star - Real-time Process Simulation using Lattice-Boltzmann on GPUs - Dr John Tomas

13:45pm - 14:45pm - Stirred tanks: Work horse of process industries + Single phase flows and mixing - Prof. Harry Van Den Akker

14:45pm - 15:45pm - Multiphase flows and mixing - Prof. Vivek Ranade

16:00pm - 16:30pm - Using Digital Twins to Simulate Single and Multiphase Flows - Dr John Tomas

DAY TWO: Friday, March 20: Demonstrations

9:00am to 9:30am - Morning demonstration

13:30pm to16:30pm - Afternoon demonstration

Participants will have two demonstrations one in the morning and one in the afternoon.

Workshop 1: Hands on session with MixIT. Use of MixIT to solve solid-liquid, Liquid-liquid and gas-liquid mixing problems with Dr Gopal Rameshchandra Kasat.

Workshop 2: “Building Digital Twins of Bioprocessing Equipment”. The topics discussed in this training would be setting-up simulations, numerical considerations, runtime performance, and analysis techniques. Topics of discussion will include solid-liquid, liquid-liquid and gas-liquid mixing problems with Dr John Thomas



  • Participants are encouraged to bring their own workstation/laptop. Participants will be provided with a trial licence of M Star CFD and MixIT for the training session. Minimum spec for M Star is a laptop/workstation with a recent (<3 year old) NVIDA GPU.
  • Minimum specification for MixIT is Window 64bit, Quad Core CPU with 8 GB of RAM.



Harry Van den Akker

Harry is Bernal Professor of Fluid Mechanics at the University of Limerick and Professor in Transport Phenomena, Delft University of Technology. Prior to joining the TUDelft, Professor Van den Akker was a research engineer at Shell Research in Amsterdam. He has held visiting appointments in Princeton and at King’s College London. He was President of the Dutch Physical Society for 6 years, and Scientific Director of the Netherlands Research School in Process Technology for 12 years. His expertise area is in fluid mechanics, turbulence, multiphase flow and transport phenomena.

Vivek Ranade

Vivek is the Bernal Chair Professor of Process Engineering at the University of Limerick. His research focuses on developing insights, innovations & intensified solutions for sustainable energy, water and chemicals including healthcare sector. He uses computational flow modelling, hydrodynamic cavitation and MAGIC (modular, agile, intensified & continuous) processes to achieve this. Before moving to Ireland, he led chemical engineering at CSIR – National Chemical Laboratory, Pune, India. He has developed several performance enhancement solutions, software products and fluidic devices for variety of applications which are commercialised. He has co-founded two companies: Tridiagonal Solutions (www.tridiagonal.com) and Vivira Process Technologies (www.vivira.in).

M-Star CFD

M-Star Simulations, LLC, is a software company focused on the development of computational tools for modelling momentum, energy and mass transport within engineering and biological systems. By pairing modern algorithms with graphical processing card (GPU) architectures, this software enables users to quickly perform calculations with predictive fidelity that rivals physical experiment. These outcomes are achieved using a simple graphical interface that requires minimal user specification and setup times. Founded in 2014, M-Star Simulations has grown to include commercial, government, and academic users across North America, South America, Europe, and Asia.

John Thomas

John Thomas is the founding President of M-Star Simulations and oversees all client support and engagement. Prior to founding M-Star Simulations, John was a research professor at Johns Hopkins University. He holds a PhD from Carnegie Mellon University and an MBA from Georgetown University.


MixIT is the next generation collaborative mixing analysis and scale-up tool designed to facilitate comprehensive stirred tank analysis using lab and plant data, empirical correlations and advanced 3D CFD models. It combines knowledge management tools and mixing science in a unified environment deployable enterprise-wide. MixIT provides a platform to analyze your mixing process across various scales and configurations including non-standard reactor geometries. It helps optimize the mixing process performance for Liquid-Liquid, Gas-Liquid and Solid-Liquid mixing.

Gopal Rameshchandra Kasat

Gopal is Project Manager at Tridiagonal Solutions with over 10 years of experience in mixing, equipment sizing & design, scale-up, characterizing multiphase flows in process equipments using Computational Fluid Dynamics and Experimental Fluid Dynamics. He holds a PhD degree in Chemical Engineering from UICT Mumbai, India.


SSPC Platform Research Modelling Theme meeting

Morning of Day 1 is the Modelling Theme meeting which is a summary meeting for all those involved in the Modelling Platform Research Programme. This is a members only meeting. Non members can join us for lunch at 12:30pm on Thursday, 19th.

Non members can email John.Brennan@sspc.ie to learn how to engage with SSPC.


Castletroy Park Hotel. There is a preferred rate if you quote the University of Limerick when booking.


Further Information

Enquires: to john.brennan[at]sspc.ie

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SSPC SFI Research Centre for Pharmaceuticals

University of Limerick



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